Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease.

摘要: Circadian clock proteins form an autoregulatory feedback loop that is central to the endogenous generation and transmission of daily rhythms in behavior physiology. Increasingly, circadian gene expression are being reported diverse tissues brain regions lie outside suprachiasmatic nucleus (SCN), master mammals. For many these extra-SCN rhythms, however, region-specific implications still emerging. In order gain important insights into potential behavioral, physiological, psychological relevance oscillations, researchers have begun focus on describing neurochemical, hormonal, metabolic, epigenetic contributions regulation rhythms. This review will highlight sites sources control within dopaminergic striatal circuitries discuss for psychopathology disease . example, dorsal striatum sensitive changes dopamine release, which has Parkinson’s drug addiction. Rhythms ventral limbic forebrain physical stressors, may major depressive disorder. Collectively, a rich tapestry emerged forces us expand traditional views reconsider psychopathological, physiological importance areas not immediately linked with