The p22 phox polymorphism C242T is not associated with CHD risk in Asian Indians and Chinese.
作者： Saha , Sanghera , Kamboh
DOI: 10.1046/J.1365-2362.1999.00575.X
关键词:
摘要: Background Oxygen free radicals such as superoxide anion have been implicated in the pathogenesis of atherosclerosis and coronary heart disease (CHD). The nonglycosylated 22 kDa α-subunit NADH/NADPH oxidase (p22 phox) vasculature acts final electron transporter generation anion. Recently, a common polymorphism (C242T) at codon 72 p22 phox gene has reported to be associated with CHD risk. Study design We examined role C242T risk biracial sample Asian Indians Chinese from Singapore. comprised angiographically confirmed patients (126 151 Chinese) age- sex-matched healthy control subjects (154 167 Chinese). Results The frequency T allele was significantly higher Indian than (0.38 vs. 0.09; P < 0.0001). However, there no difference this between case either (0.10 0.09) or 0.40). This also not plasma lipid apolipoprotein levels any group. Conclusions The is present samples Chinese.
sci-hub.se 参考文章(15)
W J Ewens, R S Spielman, R E McGinnis, Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). American Journal of Human Genetics. ,vol. 52, pp. 506- 516 ,(1993)
Toshiki Fukui, Nobukazu Ishizaka, Sanjay Rajagopalan, Jørn Bech Laursen, Quinn Capers, W. Robert Taylor, David G. Harrison, Hector de Leon, Josiah N. Wilcox, Kathy K. Griendling, p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats Circulation Research. ,vol. 80, pp. 45- 51 ,(1997) , 10.1161/01.RES.80.1.45
Michael Boehnke, Carl D. Langefeld, Genetic association mapping based on discordant sib pairs: the discordant-alleles test. American Journal of Human Genetics. ,vol. 62, pp. 950- 961 ,(1998) , 10.1086/301787
M C Dinauer, E A Pierce, G A Bruns, J T Curnutte, S H Orkin, Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. Journal of Clinical Investigation. ,vol. 86, pp. 1729- 1737 ,(1990) , 10.1172/JCI114898
Thomson G, Mapping disease genes: family-based association studies. American Journal of Human Genetics. ,vol. 57, pp. 487- 498 ,(1995)
Steve Horvath, Nan M. Laird, A discordant-sibship test for disequilibrium and linkage : No need for parental data American Journal of Human Genetics. ,vol. 63, pp. 1886- 1897 ,(1998) , 10.1086/302137
K Hughes, K C Lun, P P Yeo, Cardiovascular diseases in Chinese, Malays, and Indians in Singapore. I. Differences in mortality. Journal of Epidemiology and Community Health. ,vol. 44, pp. 24- 28 ,(1990) , 10.1136/JECH.44.1.24
Toshiki Fukui, Bernard Lassègue, Hisashi Kai, R.Wayne Alexander, Kathy K. Griendling, Cytochrome b-558 alpha-subunit cloning and expression in rat aortic smooth muscle cells. Biochimica et Biophysica Acta. ,vol. 1231, pp. 215- 219 ,(1995) , 10.1016/0005-2728(95)00098-4
D. CURTIS, Use of siblings as controls in case‐control association studies Annals of Human Genetics. ,vol. 61, pp. 319- 333 ,(1997) , 10.1046/J.1469-1809.1998.6210089.X
R Wayne Alexander, None, Hypertension and the Pathogenesis of Atherosclerosis: Oxidative Stress and the Mediation of Arterial Inflammatory Response: A New Perspective Hypertension. ,vol. 25, pp. 155- 161 ,(1995) , 10.1161/01.HYP.25.2.155