Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1

摘要: Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele rs1835740 on chromosome 8q22.1 to be associated (P = 5.38 x 10(-)(9), odds ratio 1.23, 95% CI 1.150-1.324) in genome-wide association study 2,731 cases ascertained three European clinics 10,747 population-matched controls. The was replicated 3,202 40,062 controls an overall meta-analysis P value 1.69 10(-)(1)(1) (odds 1.18, 1.127-1.244). located between MTDH (astrocyte elevated gene 1, also known as AEG-1) PGCP (encoding plasma glutamate carboxypeptidase). In expression quantitative trait lymphoblastoid cell lines, transcript levels were found significant correlation 3.96 10(-)(5), permuted threshold significance 7.7 10(-)(5). To our knowledge, data establish first risk factor migraine.