Preferential recognition of synthetic peptides from HTLV-I gp21 envelope protein by HLA-DRB1 alleles associated with HAM/TSP (HTLV-I-associated myelopathy/tropical spastic paraparesis)
作者： Yoshihisa Yamano , Bernd Kitze , Shinji Yashiki , Koichiro Usuku , Toshinobu Fujiyoshi
DOI: 10.1016/S0165-5728(97)00041-6
关键词:
摘要: To determine CD4+ T-cell epitopes of HTLV-I-envelope protein recognized by the HLA alleles associated with HAM/TSP, we established 20 lines from peripheral blood mononuclear cells (PBMCs) naive healthy donors using a panel synthetic peptides spanning entire length proteins, gp46 and gp21. We quantitated precursor frequencies HTLV-1-envelope specific T-cells analyzed epitope specificity in context alleles. The ranged 3.0 to 10.6 per 10(7) PBMCs donors. were clustered amino acids 76 90, 136 160, 171 185 196 210 gp46, 366 400 436 485 gp21 preferentially HLA-DRB1 0101 1502 which known be HAM/TSP. Thus, it was suggested that HTLV-I might contain major
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