Association between HLA alleles and HAM/TSP in individuals infected with HTLV-1.
作者： Ana Treviño , Jose L. Vicario , Mariola Lopez , Patricia Parra , Rafael Benito
DOI: 10.1007/S00415-013-7014-Z
关键词:
摘要: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) develops in less than 5 % of HTLV-1 carriers. It is unclear which factors trigger the development disease. The aim this study was to explore influence HLA alleles on HAM/TSP. A total 40 HTLV-1-infected individuals belonging Spanish cohort were examined. proviral load measured by real-time polymerase chain reaction. class I (A, B, C) and II (DRB1, DQB1) genotyped using bead array technology. Median 12 HAM/TSP patients greater 28 asymptomatic carriers (637 vs. 71 copies per 104 peripheral blood mononuclear cells; p = 0.006). Moreover, significantly associated with HLA-B*07 HLA-DRB1*01:01 (p 0.039). Interestingly, these had 0.036). In summary, testing should be considered close monitoring along periodic neurological evaluations prioritized
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