Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma
作者： Liyun Fu , Ting Yao , Qingqing Chen , Xiaoyan Mo , Yaoren Hu
DOI: 10.18632/ONCOTARGET.16881
关键词:
摘要: Circular RNAs (circRNAs) have been emerged as an indispensable part of endogenous RNA network. However, the expression significance circRNAs in hepatocellular carcinoma (HCC) is rarely revealed. The aim this study was to determine circRNA profile HCC, and investigate their clinical significances relevant mechanisms for cancer progression. global HCC measured by microarray. Levels one representative circRNAs, hsa_circ_0004018, were confirmed real-time reverse transcription-polymerase chain reaction. levels hsa_circ_0004018 significantly lower compared with para-tumorous tissue (P<0.001). Our data further showed that correlated serum alpha-fetoprotein (AFP) level, tumor diameters, differentiation, Barcelona Clinic Liver Cancer stage Tumor-node-metastasis stage. More importantly, we detected liver tissues from chronic hepatitis, cirrhosis patients; found harbored HCC-stage-specific features diverse diseases area under receiver operating characteristic curve up 0.848 (95% CI=0.803-0.894, P<0.001). sensitivity specificity 0.716 0.815, respectively. Finally, might be involved cancer-related pathways via interactions miRNAs.
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