摘要: BACKGROUND Although hematologic malignancies and some solid tumors such as germ cell pediatric can be cured by cytotoxic treatment, the most prevalent are relatively resistant to these interventions. Apoptosis is involved in kill of anticancer drugs p53 believed principal importance this process. However also plays a role cycle arrest DNA repair, cellular processes that decrease sensitivity chemotherapy. Therefore, may play dual after exposure activating either mechanisms lead apoptosis or launching directing repair survival cell. DESIGN In article, we review details functions mediation chemosensitivity. The preclinical clinical data published recent years about relation between chemosensitivity discussed potential pitfalls associated studies, account for contradictory results produced so far mentioned.
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