Osteoporosis in lung transplantation candidates with end-stage pulmonary disease

摘要: purpose Fractures, a common complication of cardiac and liver transplantation, have not been reported in association with lung transplantation. However, many patients end-stage pulmonary disease multiple risk factors for osteoporosis, several studies suggested that osteoporosis before transplantation may increase the fracture after Therefore, we evaluated group who were awaiting to determine prevalence osteoporosis. methods Seventy (aged 18–70 years) consecutively bone densitometry by dual-energy x-ray absorptiometry. The predominantly Caucasian (96%). Bone mass was expressed as mineral density (BMD; g/cm 2 ), number standard deviations (SD) below peak (T score), apparent (BMAD; 3 measurement minimizes effects size on BMD. Spine radiographs obtained subset 50 consecutive detect vertebral compression fractures. Vitamin D status assessed serum concentrations 25-hydroxyvitamin D. sorted into groups diagnosis: chronic obstructive (COPD; n=28); cystic fibrosis (n = 11); idiopathic fibrosis; other diseases (Other; n=31). results: In whole, score −2.5) present 30% at lumbar spine 49% femoral neck. Osteopenia between −1 an additional 35% 31% average neck T COPD fell osteoporotic range (−2.7 ± 0.3 −2.6 0.3, respectively), significantly ( P 0.008). Other glucocorticoids had mild osteopenia (0.972 0.06 ; T=−1.2 0.6). Very few any regimen prevent conclusions Osteoporosis vitamin deficiency are extremely disease. Only 34% normal BMD only 22% hip. Patients glucocorticoid-treated most severely affected. Therapies loss treat established uncommonly utilized Candidates should be time acceptance transplant waiting list.