Tumour Promoters Induce Macrophage Differentiation in Human Myeloid Cells from Patients with Acute and Chronic Myelogenous Leukaemia
作者： E. Fibach , E. A. Rachmilewitz
DOI: 10.1111/J.1365-2141.1981.TB02780.X
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摘要: Summary. Twelve-O-tetradecanoyl phorbol-13-acetate (TPA) and other tumour promoter plant diterpenes transformed myeloid cells from peripheral blood, bone marrow spleen patients with chronic acute leukaemia myelomonocytic into macrophage-like cells. This transformation resulted in cessation of cell multiplication, adherence the to surface culture dish, acquisition phagocytic activity, Fc receptors enzymatic content characteristic monocyte-macrophage pathway differentiation. The fact that promoters induce differentiation human not similar non-leukaemic conditions suggest their possible application diagnosis chemotherapy.
sci-hub.se 参考文章(26)
I. Berenblum, Carcinogenesis and Tumor Pathogenesis Advances in Cancer Research. ,vol. 2, pp. 129- 175 ,(1954) , 10.1016/S0065-230X(08)60493-5
Richard A. Rifkind, Paul A. Marks, I. Bernard Weinstein, Hiroshi Yamasaki, Eitan Fibach, Tumor Promoter-induced Adhesion of the DS19 Clone of Murine Erythroleukemia Cells Cancer Research. ,vol. 39, pp. 1989- 1994 ,(1979)
E. Fibach, M. Hayashi, L. Sachs, Control of Normal Differentiation of Myeloid Leukemic Cells to Macrophages and Granulocytes Proceedings of the National Academy of Sciences. ,vol. 70, pp. 343- 346 ,(1973) , 10.1073/PNAS.70.2.343
G. Rovera, T. G. O'Brien, L. Diamond, Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture Proceedings of the National Academy of Sciences of the United States of America. ,vol. 74, pp. 2894- 2898 ,(1977) , 10.1073/PNAS.74.7.2894
M Artman, R. Seeley, Nicotinamide adenine dinucleotide splitting enzyme: a characteristic of the mouse macrophage Science. ,vol. 202, pp. 1293- 1295 ,(1978) , 10.1126/SCIENCE.214853
J. Lotem, L. Sachs, Different blocks in the differentiation of myeloid leukemic cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 71, pp. 3507- 3511 ,(1974) , 10.1073/PNAS.71.9.3507
S. J. Collins, F. W. Ruscetti, R. E. Gallagher, R. C. Gallo, Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 75, pp. 2458- 2462 ,(1978) , 10.1073/PNAS.75.5.2458
E. Fibach, R. Gambari, P. A. Shaw, G. Maniatis, R. C. Reuben, S. Sassa, R. A. Rifkind, P. A. Marks, Tumor promoter-mediated inhibition of cell differentiation: suppression of the expression of erythroid functions in murine erythroleukemia cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 1906- 1910 ,(1979) , 10.1073/PNAS.76.4.1906
LEILA DIAMOND, THOMAS G. O'BRIEN, GIOVANNI ROVERA, Inhibition of adipose conversion of 3T3 fibroblasts by tumour promoters Nature. ,vol. 269, pp. 247- 249 ,(1977) , 10.1038/269247A0
C. Y. LI, L. T. YAM, K. W. LAM, Esterases in human leukocytes. Journal of Histochemistry and Cytochemistry. ,vol. 21, pp. 1- 12 ,(1973) , 10.1177/21.1.1