Macrophage Differentiation of Human Precursor B-Cell Line by Phorbol Ester and Colony-Stimulating Factor
作者： A Hiraoka , K Kubota , HD Preisler , J Minowada
DOI: 10.1182/BLOOD.V59.5.997.997
关键词:
摘要: A human round cell line, KLM-2, is considered to be precursor B-cell by immunologic surface marker analysis and histochemical studies. The effect of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and/or colony- stimulating factor (CSF) on KLM-2 cells was investigated. became adherent the bottom flask day 2 after liquid culture with TPA, number macrophage-like (mAC) pseudopodia showed a TPA dose-dependent increase peak level 3 or 4. mAC had phagocytic activity. suspending were positive for alpha-naphthyl acetate esterase (NAE) up about 50% in TPA. concentration 100 ng/ml optimal provide maximum NAE-positive cells. Particularly, such effects markedly accelerated presence CSF. These findings indicate macrophage differentiation may bipotential stem line differentiating into monocyte-macrophage lineages.
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sci-hub.se 参考文章(12)
JF Di Persio, JK Brennan, MA Lichtman, BL Speiser, Human cell lines that elaborate colon-stimulating activity for the marrow cells of man and other species. Blood. ,vol. 51, pp. 507- 519 ,(1978) , 10.1182/BLOOD.V51.3.507.507
L A Herzenberg, F D Howard, J Wong, E B Stinson, C P Bieber, J A Ledbetter, A human T lymphocyte differentiation marker defined by monoclonal antibodies that block E-rosette formation Journal of Immunology. ,vol. 126, pp. 2117- 2122 ,(1981)
G. Rovera, D. Santoli, C. Damsky, Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 2779- 2783 ,(1979) , 10.1073/PNAS.76.6.2779
Mary C. Territo, H. Phillip Koeffler, Induction by Phorbol Esters of Macrophage Differentiation in Human Leukaemia Cell Lines does not Require Cell Division British Journal of Haematology. ,vol. 47, pp. 479- 483 ,(1981) , 10.1111/J.1365-2141.1981.TB02816.X
H P Koeffler, M Bar-Eli, M Territo, Phorbol diester-induced macrophage differentiation of leukemic blasts from patients with human myelogenous leukemia. Journal of Clinical Investigation. ,vol. 66, pp. 1101- 1108 ,(1980) , 10.1172/JCI109939
Maura R. Levine, Rody P. Cox, Use of latex particles for analysis of heterokaryon formation and cell fusion. Somatic Cell and Molecular Genetics. ,vol. 4, pp. 507- 512 ,(1978) , 10.1007/BF01538870
S. M. Fu, J. N. Hurley, Human cell lines containing Epstein-Barr virus but distinct from the common B cell lymphoblastoid lines Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 6637- 6640 ,(1979) , 10.1073/PNAS.76.12.6637
E. Huberman, M. F. Callaham, Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 1293- 1297 ,(1979) , 10.1073/PNAS.76.3.1293
JM McCune, SM Fu, HG Kunkel, None, J chain biosynthesis in pre-B cells and other possible precursor B cells. Journal of Experimental Medicine. ,vol. 154, pp. 138- 145 ,(1981) , 10.1084/JEM.154.1.138
E. Fibach, E. A. Rachmilewitz, Tumour Promoters Induce Macrophage Differentiation in Human Myeloid Cells from Patients with Acute and Chronic Myelogenous Leukaemia British Journal of Haematology. ,vol. 47, pp. 203- 210 ,(1981) , 10.1111/J.1365-2141.1981.TB02780.X