Identification of Dp71e, a new dystrophin with a novel carboxy‐terminal end

摘要: Several dystrophin Dp71 isoforms have previously been described and can be grouped into two subfamilies (Dp71d or Dp71f) depending upon the splicing of exon 78. As a consequence this splicing, each group has carboxy-terminal end with unique amino acid composition; composition imparts specific characteristics respect to subcellular localization interactions particular members dystrophin-associated proteins (DAPs) complex. We discovered new alternative event at 3′ region transcript. This spliced sequence that codes for 10 acids prevents translation exons 78 79. novel isoform is called Dp71e expressed in undifferentiated cells during nerve growth factor-induced differentiation PC12 cells. Interestingly, mRNA protein expression increase cell mediated by NGF. also rat organs human lines. Database Dp71e nucleotide data are available GenBank/EMBL/DDBJ databases under accession number JF510048.1