Photo-crosslinked copolymers of 2-hydroxyethyl methacrylate, poly(ethylene glycol) tetra-acrylate and ethylene dimethacrylate for improving biocompatibility of biosensors
作者： Chris P. Quinn , Chandrashekhar P. Pathak , Adam Heller , Jeffrey A. Hubbell
DOI: 10.1016/0142-9612(95)98856-9
关键词:
摘要: A copolymer containing 88% 2-hydroxyethyl methacrylate (HEMA), 9% poly(ethylene glycol) (MW 18.5 kDa) tetra-acrylate and 3% ethylene dimethacrylate was prepared evaluated for use as a biocompatible interface between glucose biosensors tissue in the rat. The sensor utilizes oxidase that is electrically 'wired' to gold current collector by reduction-oxidation polymer. Coatings of were crosslinked situ on sensors using long wavelength ultraviolet light 2,2-dimethoxy-2-phenyl-acetophenone initiator. effect these films had response measured. Over concentration range 0-30 mM, average percentage decrease 45 +/- 28% (mean 95% confidence interval) at 37 degrees C about 0.1 mm thick, an acceptable value. Copolymer-treated control electrodes implanted intrascapular subcutaneous male Sprague-Dawley rats three days. explanted samples scanning electron microscopy. highly encapsulated with fibrous material, while copolymer-treated induced much less encapsulation. results show this be candidate coating wired oxidoreductase-based biosensors.
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