Fabrication of thermoplastic polyurethane tissue engineering scaffold by combining microcellular injection molding and particle leaching
作者： Hao-Yang Mi , Xin Jing , Max R. Salick , Lih-Sheng Turng , Xiang-Fang Peng
DOI: 10.1557/JMR.2014.67
关键词:
摘要: Microcellular injection molding, a process capable of mass-producing complex plastic parts, and particle leaching methods were combined to fabricate porous thermoplastic polyurethane tissue engineering scaffolds. Water soluble polyvinyl alcohol (PVOH) sodium chloride (NaCl) used as porogens improve the porosity interconnectivity well hydrophilicity It was found in study that microcellular molding effective at producing high pore density porosity. The addition PVOH decreased diameter increased density. Furthermore, scaffolds with NaCl showed more interconnected pores. 3T3 fibroblast cell culture confirm biocompatibility Residual content after further improved adhesion proliferation. resulting offer an alternative scalable scaffold fabrication method for soft production.
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M. Navarro, C. Aparicio, M. Charles-Harris, M. P. Ginebra, E. Engel, J. A. Planell, Development of a Biodegradable Composite Scaffold for Bone Tissue Engineering: Physicochemical, Topographical, Mechanical, Degradation, and Biological Properties Advances in Polymer Science. ,vol. 200, pp. 209- 231 ,(2006) , 10.1007/12_068
Ayer Burke, Nesrin Hasirci, Polyurethanes in Biomedical Applications ,(1997)
Zhichao Tian, Yuanli Zhu, Jinjun Qiu, Hanfeng Guan, Liangyu Li, Shouchao Zheng, Xuehai Dong, Jun Xiao, Synthesis and characterization of UPPE-PLGA-rhBMP2 scaffolds for bone regeneration Journal of Huazhong University of Science and Technology [Medical Sciences]. ,vol. 32, pp. 563- 570 ,(2012) , 10.1007/S11596-012-0097-4
L. Shor, E. D. Yildirim, S. Güçeri, W. Sun, Precision Extruding Deposition for Freeform Fabrication of PCL and PCL-HA Tissue Scaffolds pbnp. pp. 91- 110 ,(2010) , 10.1007/978-1-4419-1395-1_6
Alvin Yeo, Wah Jie Wong, Swee-Hin Teoh, Surface modification of PCL-TCP scaffolds in rabbit calvaria defects: Evaluation of scaffold degradation profile, biomechanical properties and bone healing patterns Journal of Biomedical Materials Research Part A. ,vol. 93, pp. 1358- 1367 ,(2009) , 10.1002/JBM.A.32633
Linda J. Gerhardt, Charles W. Manke, Esin Gulari, Rheology of polydimethylsiloxane swollen with supercritical carbon dioxide Journal of Polymer Science Part B. ,vol. 35, pp. 523- 534 ,(1997) , 10.1002/(SICI)1099-0488(199702)35:3<523::AID-POLB11>3.0.CO;2-J
Kai He, Xiaohong Wang, Rapid prototyping of tubular polyurethane and cell/hydrogel constructs: Journal of Bioactive and Compatible Polymers. ,vol. 26, pp. 363- 374 ,(2011) , 10.1177/0883911511412553
Xinwen Wang, Peter Lin, Qizhi Yao, Changyi Chen, Development of Small-Diameter Vascular Grafts World Journal of Surgery. ,vol. 31, pp. 682- 689 ,(2007) , 10.1007/S00268-006-0731-Z
Bhuvanesh Gupta, Shamayita Patra, Alok R. Ray, Preparation of porous polycaprolactone tubular matrix by salt leaching process Journal of Applied Polymer Science. ,vol. 126, pp. 1505- 1510 ,(2012) , 10.1002/APP.36922
Devang Odedra, Loraine Chiu, Lewis Reis, Fiona Rask, Katherine Chiang, Milica Radisic, Cardiac tissue engineering Current opinion in chemical engineering. ,vol. 2, pp. 421- 456 ,(2013) , 10.1007/978-3-7091-0385-2_15