Non-myeloablative/lymphoablative conditioning regimen to induce patient anti-donor unresponsiveness in stem cell transplantation

摘要: Serious hematologic malignancies are treated through high dose or lethal chemotherapy and/or radiation therapy conditioning regimens followed by rescue with allogeneic stem cell transplantation (allo-SCT) autologous (ASCT). These myeloablative/lymphoablative (M/L) treatment involve the elimination of both patient's hematopoietic cells and T-lymphocytes, often leading to serious complications including graft versus host disease (GVHD). The claimed invention addresses some these problems providing a regimen that is designed eliminate T-lymphocytes while retaining functional population (HSC). This non-myeloablative/lymphoablative (-/L) involves administration one more agents such as purine analogs (e.g., fludarabine), alkylating bisulfan, cyclophosphamide), anti-leukocyte globulins anti-T lymphocyte globulin). After this, donor-derived preparation administered patient. Patients according develop donor-specific unresponsiveness relatively fewer compared standard M/L regimens. methodologies should prove useful in number chronic myelogenous leukemia, acute lymphoblastic non-Hodgkin's lymphoma.