The chequered history of malaria control: are new and better tools the ultimate answer?

摘要: Following Ronald Ross' demonstration in 1897 that mosquitoes transmit malarial parasites, efforts to control malaria were naturally focussed on attacking the mosquito vector by various measures, mainly directed against aquatic stages. Although results spectacular some areas, there was a growing realisation effective of depended other factors, including availability better drugs than quinine and greater understanding epidemiology disease under environmental conditions. With discovery DDT, an all-out effort made eradicate adult mosquitoes. Eradication not achieved many countries, because inadequate health infrastructures. emergence chloroquine-resistant search for more drug regimens intensified, combinations assessed, methods developed monitor assess degrees resistance. Since resistance can develop very quickly, use combinations, especially those containing artemisinin derivatives, is now recommended. Insecticide-impregnated bednets have become preferred method control. tools must continue, events past century emphasise need strengthen systems ensure they are capable delivering interventions assessing their effectiveness controlling malaria.