Risk association of meningiomas with MTHFR C677T and GSTs polymorphisms: a meta-analysis.

摘要: Previous studies have shown that the single nucleotide polymorphisms (SNPs) in Methylenetetrahydrofolate reductase (MTHFR) and Glutathione S-transferases (GSTs, including GSTM1, GSTT1) genes play an important role determining response of individual to environmental pathogenesis significantly relate incidences various human tumors, brain tumors. However, these genes’ on meningioma risk remains poorly understood. The relevant inferences from previous are hindered by their limited statistical power conflicting results. aim this meta-analysis is provide a relatively comprehensive account association between risk. A literature search for eligible published before January 1, 2014 was conducted PubMed, Embase, Web Science, Cochrane Library, CNKI databases. Pooled odds ratios (OR) with corresponding 95% confidence intervals (95% CI) were used evaluate strength under fixed or random effect model according heterogeneity test Heterogeneity publication bias evaluated. All analyses using software STATA 12.0 (STATA Corporation, College Station, TX, USA). For MTHFR C677T (dbSNP: rs1801133) (C T) polymorphism, 9 case-control six publications 1,615 cases 1,909 controls obtained. GSTM1 null there 4 417 1,735 controls. GSTT1 405 1,622 combined results show carriers CT genotype may be associated higher (OR = 1.20, CI 1.05-1.38, P 0.009). Stratified Caucasians if they carry 1.31, 1.05-1.63, 0.02). Risk carrying TT + also 1.27, 1.02-1.58, 0.03). not different compared control population 0.96, 0.69-1.34, 0.82). enrolled about GSTM1/GSTT1 Caucasians. pooled ORGSTM1 ORGSTT1 significant Caucasian population. These indicate SNPs related ethnic differences. susceptibility.