Perinatal food restriction impaired spatial learning and memory behavior and decreased the density of nitric oxide synthase neurons in the hippocampus of adult male rat offspring.
作者： Yinguo Zhang , Ning Li , Zhuo Yang
DOI: 10.1016/J.TOXLET.2010.01.002
关键词:
摘要: Perinatal undernutrition has adverse effects on brain physiology as well learning and memory activity. However, the mechanism is still incompletely understood. Nitric oxide (NO) synthesized by neuronal nitric synthase (nNOS) important roles in survival synaptic plasticity contributes to task. The aims of present study were investigate whether 50% perinatal food restriction (FR50) produced deleterious population nNOS neurons CA1 CA3 dentate gyrus (DG) region hippocampus using ABC immunohistochemical method. results showed FR50 reduced body weight offspring postnatal day (PD)1, PD7, PD10, PD14 PD21, this type impaired adult male rats (postnatal 70) decreased density nNOS-positive cells CA1, DG hippocampus. These findings suggest that affects activity Thus, these changes may partly explain disturbances commonly observed undernourished provide clues knowledge malnutrition upon brain.
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