Chemical mixtures: challenge for toxicology and risk assessment.

摘要: It is now well-recognized that human environmental exposures are not to single chemicals. Rather, humans exposed, either concurrently or sequentially, multiple Challenges chemical mixtures pose for risk assessment and toxicology presented. Challenge areas include increasing the peer-reviewed publication of studies, improving access data examining target organs. Two difficult challenges development a common, consistent language use appropriate innovative experimental designs analyses. The challenge elucidation mechanism(s) offers rational basis extrapolation across dose levels, exposure durations routes as well other species similar Of particular importance focusing effort on those investigation where answers have greatest potential reducing uncertainty in assessments impact health. A particularly fruitful area future determination likelihood nonadditive interactions exposed chemicals at levels.