Stress hormones given to healthy volunteers alter the concentration and configuration of ribosomes in skeletal muscle, reflecting changes in protein synthesis.

摘要: 1. The influence of elevated concentrations stress hormones on the concentration ribosomes and relative proportion polyribosomes, reflecting protein synthesis in vivo, human skeletal muscle was investigated. Healthy volunteers were given a 6 h infusion adrenaline (n = 8), cortisol triple-hormone combination adrenaline, glucagon or saline 8). 2. total ribosome declined by 30.4 +/- 7.2% group (P less than 0.01), 26.9 8.6% 0.05) 24.8 11.2% 0.05). polyribosomes to decreased 8.5 2.2% 3. During hormone serum glucose levels enhanced. insulin group, but not group. Serum control 4. results indicate an effect combined as well abundance polyribosomes. single influenced only. suggest critical role for producing decline seen after trauma.