Intratumoral molecular or genetic markers as predictors of clinical outcome with chemotherapy in colorectal cancer

摘要: Identification of molecular markers at either the intragenic, chromosomal, mRNA, or protein level that might predict whether colorectal cancer patients are likely to benefit from adjuvant palliative therapy is a high priority. The majority clinical studies addressing this issue, particularly those done in setting, analyzed tumor samples treated era when 5-fluorouracil (5-FU) alone combined with leucovorin levamisole were mainstay therapy. This review highlights some intratumoral may have importance as predictors 5-FU-based Although goal these investigations one day permit selection for an individual patient based on phenotype, prospective yet be conducted test results improved outcome.