Role of bile acid secretion in human colorectal cancer
作者： Meinrad Peterlik
DOI: 10.1007/S10354-008-0601-4
关键词:
摘要: Cholic, deoxycholic and lithocholic acid promote tumor formation in the large intestine by a direct proliferative effect on rather undifferentiated mucosal epithelial cells. In addition, bile acids may play role colorectal cancer pathogenesis because they reduce chemopreventive efficiency of calcium vitamin D interfering with receptor-activated anti-mitogenic intracellular signalling neoplastic colonocytes.
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