Risk factors and molecular characterization of acute sporadic symptomatic hepatitis E virus infection in Thailand
作者： Kittiyod Poovorawan , Salyavit Jitmitrapab , Sombat Treeprasertsuk , Thanunrat Thongmee , Apiradee Theamboonlers
DOI: 10.1016/S1995-7645(14)60121-8
关键词:
摘要: Abstract Objective To report clinical outcomes and viral genotypes of acute symptomatic hepatitis E virus (HEV) infection in Thailand. Methods Forty patients with HEV were recruited during 2009-2013. Clinical, demographic laboratory data collected. Diagnosis was accomplished by detection anti-HEV IgM and/or RNA the serum or stool. classified direct sequencing RT-PCR products phylogenetic analysis. Results The high risk group, comprising immune-compromised, liver cirrhosis very elderly (>80 years) (17 cases), had higher levels alkaline phosphatase at presentation compared low group. Two fatal cases resulted from Initial did not show statistically significant differences. In six (6/40), could be detected stool sequencing. Upon molecular characterization, viruses as genotype 3f same cluster Thai swine HEV. Conclusions Our showed that has various presentations outcomes. Higher observed patients. All isolated identified possibly originating swine.
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