Increased Expression of Germinal Center–Associated Nuclear Protein RNA-Primase Is Associated with Lymphomagenesis
作者： Satoru Fujimura , Yan Xing , Motohiro Takeya , Yasuyuki Yamashita , Koichi Ohshima
DOI: 10.1158/0008-5472.CAN-04-3259
关键词:
摘要: Lymphomas arise containing abnormalities of various differentiation stage-specific molecules. In the study reported here, we have shown abnormal up-regulation germinal center B cell-associated GANP in human lymphomas including mantle cell, diffuse large and Hodgkin lymphoma, by immunohistochemical analysis. To role lymphomagenesis, generated mutant mice (ganp-Tg) that express transgenic ganp gene under immunoglobulin enhancer promoter control. Ganp-Tg showed a high incidence lymphomagenesis (29.5%) after aging with non-B/non-T cell surface phenotype having slight CD45R/B220 expression Ig transcripts rearranged VH-DH-JH IgH loci. ganp-Tg displayed similar pathologic characteristics to mouse reticulum neoplasm or lymphoma-like lesions. The VH sequences individual tumors proliferated from single clone oligoclones, as is found B-cell lymphoma. These results suggest overexpression causative factor generation lymphomas.
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