Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

作者: B. M. Gardner , D. Pincus , K. Gotthardt , C. M. Gallagher , P. Walter

DOI: 10.1101/CSHPERSPECT.A013169

关键词:

摘要: … ’s sensitivity and duration of activation. The mechanistic principles of ER stress sensing are … pathway by translocation into the endoplasmic reticulum (ER). These newly synthesized …

参考文章(75)
Linda M Hendershot, The ER function BiP is a master regulator of ER function. Mount Sinai Journal of Medicine. ,vol. 71, pp. 289- 297 ,(2004)
W. L. Delano, The PyMOL Molecular Graphics System DeLano Scientific. ,(2002)
Anne Bertolotti, Yuhong Zhang, Linda M. Hendershot, Heather P. Harding, David Ron, Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response Nature Cell Biology. ,vol. 2, pp. 326- 332 ,(2000) , 10.1038/35014014
Hiderou Yoshida, Toshie Matsui, Akira Yamamoto, Tetsuya Okada, Kazutoshi Mori, XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor Cell. ,vol. 107, pp. 881- 891 ,(2001) , 10.1016/S0092-8674(01)00611-0
R. Luke Wiseman, Yuhong Zhang, Kenneth P.K. Lee, Heather P. Harding, Cole M. Haynes, Joshua Price, Frank Sicheri, David Ron, Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. ,vol. 38, pp. 291- 304 ,(2010) , 10.1016/J.MOLCEL.2010.04.001
D T Ng, S S Watowich, R A Lamb, Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene. Molecular Biology of the Cell. ,vol. 3, pp. 143- 155 ,(1992) , 10.1091/MBC.3.2.143
Alexei V. Korennykh, Pascal F. Egea, Andrei A. Korostelev, Janet Finer-Moore, Chao Zhang, Kevan M. Shokat, Robert M. Stroud, Peter Walter, The unfolded protein response signals through high-order assembly of Ire1. Nature. ,vol. 457, pp. 687- 693 ,(2009) , 10.1038/NATURE07661