VEGF Expression in Pancreatic Cancer and Other Malignancies: A Review of the Literature.

摘要: Angiogenesis is a crucial event for tumor growth and it regulated predominantly by several different factors. Vascular endothelial factor protein family (VEGF) its receptors are probably the most important tissue factors responsible angioblast differentiation tube formation. VEGF currently comprises members: (or VEGF-A), VEGF-B, VEGF-C VEGF-D, VEGF-F, placental (PlGF), their VEGFR-1, VEGFR-2 VEGFR-3. key angiogenic level of expression critical marker detection diseases. The potent role in angiogenesis has been widely described past decade, being expressed types nondigestive digestive cancers. members play an development pancreatic cancer (especially VEGF-A, VEGF-C, VEGFR-1 VEGFR-2). VEGF-A specific prominent among all receptor evaluating cancer. Thus, overexpression may be considered as diagnostic poor prognostic disease.