Therapeutic options for the management of hot flashes in breast cancer survivors: an evidence-based review.

摘要: Abstract Background: Women with breast cancer may experiencetreatment-induced menopausal symptoms or natural menopause. Menopausal symptoms, particularly hot flashes, are reported at a high frequency in this group and tend to be more severe, distressing, of greater duration than controls. Because the contribution sex hormones cancer, use hormonal agents for control flashes is problematic these women. Safer nonhormonal alternatives recommended patient group. Objectives: This was systematic review thetherapeutic options treatment survivors. Methods: MEDLINE searched from 1990 July 2006 using disease-specific term neoplasms subheadings menopause . EMBASE March subject headings tumor/ key word The reference lists identified articles relevant were examined additional publications. Pertinent abstracts large randomized controlled trials focusing on treatrment survivors selected review. Pilot studies excluded. Results: A number nonpharmacologic approaches available survivors, although they appear limited effectiveness. Complementary alternative medicine therapies vitamin E have been found modest effectiveness best, data their long-term safety not available. Centrally active such as antidepressants venlafaxine paroxetine antiseizure agent gabapentin shown clinical reasonably well tolerated population. Conclusions: (eg, venlafaxme, paroxetine, gabapentin) regarded most promising treatments Nonpharmacologic complementarylalternative