A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study

摘要: Abstract Introduction: Circulating levels of fibrinogen are associated with atherosclerosis and predict future coronary heart disease stroke. Levels correlated among family members, suggesting a heritable component. Variants the β-fibrinogen gene subunit on 4q28 but explain only small proportion total genetic variability. It remains unknown what role, if any, is played by other variants in inter-individual variability general population. Materials methods: We conducted 10-cM spaced genome-wide scan using 402 original cohort subjects 1193 offspring from 330 extended families Framingham Heart Study. Heritability linkage analyses were carried out variance component methods. Regression performed to adjust for traditional risk factors HindIII β-148 genotypes. Results Discussions: The heritability was estimated as 0.24. highest second LOD scores found chromosomes 2 (LOD=1.5 at 243 cM) 10 (LOD=2.4 87 analysis, (LOD=2.1 242 10(LOD=1.4 86 cM), 17 (LOD=1.4 96 20 80 both offspring. These results suggest that there may be influential regions these chromosomes. While no significance detected, further research confirm our findings warranted.