Quantitative determination of fibrinogen of patients with coronary heart diseases through piezoelectric agglutination sensor.
作者： Qinghai Chen , Guoru Cai , Weiling Fu , Dongbo Liu , Ming Chen
DOI: 10.3390/S100302017
关键词:
摘要: Fibrinogen can transform fibrin through an agglutination reaction, finally forming polymer with grid structure. The density and viscosity of the reaction system changes drastically during course agglutination. In this research, we apply independently-developed piezoelectric sensor to detect fibrinogen in patients coronary heart diseases. terminal judgment method determining plasma was established. addition, standard curve between time concentration established determinate content quantitatively. results indicate close correlation STAGO paramagnetic particle for detection Fibrinogen. coefficient 0.91 (γ = 0.91). determination be completed within 10 minutes. disease group significantly higher than that healthy control (P < 0.05). reveal high is closely correlated incurrence, development prognosis Compared other traditional methods, has some merits such as operation convenience, small size, low cost, quick detecting, good precision common reacting agents method.
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