Hereditary Factors in Atrial Septal Defect

摘要: One hundred families ascertained through a proband's having atrial septal defect (ostium secundum) were studied. Selection of certain pedigrees from the overall data could lead to conclusion that is inherited as Mendelian dominant or recessive, depending on selected. Analysis this study and literature suggests multifactorial inheritance explanation most consistent with available observations. The distinction between single factor modes more than academic interest. From point view genetic counseling, risk newborn not fixed in but increases number affected relatives. prevention, environmental hazards such drugs illnesses may play an important role production defects showing inheritance.