Functions and roles of long noncoding RNA in cholangiocarcinoma.
作者： Jinglin Li , Lining Huang , Zhenglong Li , Xiangyu Zhong , Sheng Tai
DOI: 10.1002/JCP.28470
关键词:
摘要: Cholangiocarcinoma (CCA) is one of the most fatal cancers in humans, with a gradually increasing incidence worldwide. The efficient diagnostic and therapeutic measures for CCA to reduce mortality are urgently needed. Long noncoding RNAs (lncRNAs) may provide potential option suppressing development. LncRNAs type non-protein-coding RNAs, which larger than 200 nucleotides length. Increasing evidence reveals that lncRNAs exhibit critical roles carcinogenesis development CCA. Deregulation impacts proliferation, migration, invasion, antiapoptosis cells by multiple sophisticated mechanisms. Consequently, likely represent promising biomarkers or intervention targets In this review, we summarize current studies regarding biological functions regulatory mechanisms diverse
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