A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen.
作者： J.L. Vaught , Kathleen Pelley , L.G. Costa , Paulette Setler , S.J. Enna
DOI: 10.1016/0028-3908(85)90076-0
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摘要: Abstract The antinociceptive action of the γ-aminobutyric acid (GABA) agonists THIP and baclofen was evaluated in mice using hot-plate (48 55°C) tail-immersion (50°C) procedures. It found that atropine reversed antinociception induced by but not 48°C test, whereas anticholinergic drug blocked response to both GABA when stimulus provided a 55°C hot-plate. Atropine methylnitrate, mecamylamine, picrotoxin bicuculline had no effect on or baclofen. Prior treatment with haloperidol enhanced only A reciprocal cross-tolerance between assay, although exhibited morphine. These results suggest while analgesic is partially mediated common system, two agents act independent mechanisms as well.
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