作者: Deborah O. Himes , Margaret F. Clayton , Gary W. Donaldson , Lee Ellington , Saundra S. Buys
DOI: 10.1007/S10897-015-9866-0
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摘要: The most common result of BRCA1/2 mutation testing when performed in a family without previously identified is an uninformative negative test result. Women these families may have increased risk for breast cancer because mutations non-BRCA predisposition genes, including moderate- or low-risk shared environmental factors. Genetic counselors often encourage counselees to share information with members, however it unclear how much and the impact that on accuracy perception members. We evaluated 85 sisters daughters women who received results. measured using latent variable model where was represented as correlation between perceived (indicators = verbal quantitative measures) calculated Claus BRCAPRO). Participants reported more them by their sister mother about her genetic counseling session had greater (0.707, p 0.000) than those little (0.326, 0.003). However, very information; nearly 20 % members nothing counseling. Family were generally not aware existence summary letter. Our findings underscore need effective strategies facilitate sessions. Such communication help relatives better understand risks enhance appropriate prevention.