C57BL/6J and A/J mice fed a high-fat diet delineate components of metabolic syndrome.

摘要: Objective: The aim of this study was to assess the suitability A/J and C57BL/6J mice both sexes as models some components human metabolic syndrome (MetS) under nutritional conditions more comparable with actual worldwide diet responsible for increased incidence MetS. Research Methods: We fed large cohorts (n = 515) two strains mice, C57BL/6J, a high-fat (HFD; 60% fat) that, in contrast most previous reports using saturated fats, enriched mono- polyunsaturated fatty acids, thus closely mimicking Western diets, or control (10% fat), 20 weeks. Results: In sharp reports, weight gain hyperleptinemia were similar sexes. Hyperinsulinemia, glucose tolerance, insulin resistance, hypercholesterolemia observed, although important differences between males displayed severely impaired tolerance resistance. However, C57BL6/J which overt type 2 diabetes, remained normoglycemic. Discussion: With magnitude time course, phenotypic characteristics on HFD demonstrate that these are very useful identifying mechanisms underlying progression resistance subsequent diabetes.