The immunologist’s grail: Vaccines that generate cellular immunity
作者： M. A. Liu
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摘要: Many of the past efforts to develop vaccines have focused upon generation antibody responses. In a number current both new against many infectious diseases and effective immunotherapies for cancer, target has been cytotoxic T lymphocyte (CTL) Unlike B cells (and antibodies) that can recognize chemically diverse antigens (e.g., proteins, polysaccharides) in variety contexts (cell- or pathogen-associated soluble), generally only bimolecular complex consisting an antigenic peptide bound certain cell membrane glycoproteins, major histocompatibility (MHC) class I II molecules. These MHC molecules provide genetic identity each individual since parentally derived haplotype is codominantly expressed.
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