Toll-like receptor (TLR9) -1486 T/C (rs187084) gene polymorphism in Egyptian patients with rheumatoid arthritis
作者： Marwa K. Hegazy , Fatma A. Auf , Nanis O. Neseem , Mohammad F. Al-Harrass
DOI: 10.1016/J.EJR.2018.10.001
关键词:
摘要: Abstract Aim of the work The aim study was to assess role Toll-like receptor-9 (TLR9) gene polymorphism in rheumatoid arthritis (RA) and evaluate its association with disease activity severity Egyptian patients. Patients methods included 100 RA patients matched controls. Genotyping TLR9 -1486 T/C (rs187084) for all participants performed. Medical Records-Based Index Severity (RARBIS), modified Health Assessment Questionnaire (mHAQ), score (DAS28) clinical laboratory parameters were assesses Anti-cyclic citrullinated peptide antibodies (anti-CCP) factor (RF) also determined. Results mean age 43.7 ± 8.9 years 73 females 27 males duration 13.3 ± 6.2 years. DAS28 3.5 ± 1.1, RARBIS 6.6 ± 2.8 mHAQ 1.4 ± 0.8. frequency TT genotype carriers significantly higher than controls (27% 9% respectively). Similarly, T allele more frequent comparison (56.5% 42% No significant found between genotypes gender or at onset. reflecting showed no genotype. TRL9 genotyping presence RF anti-CCP antibodies. Conclusion is associated increased susceptibility
sci-hub.se 参考文章(33)
Matthias Pierer, Janine Rethage, Reinhart Seibl, Roger Lauener, Fabia Brentano, Ulf Wagner, Holm Hantzschel, Beat A. Michel, Renate E. Gay, Steffen Gay, Diego Kyburz, Chemokine Secretion of Rheumatoid Arthritis Synovial Fibroblasts Stimulated by Toll-Like Receptor 2 Ligands Journal of Immunology. ,vol. 172, pp. 1256- 1265 ,(2004) , 10.4049/JIMMUNOL.172.2.1256
Qi-Quan Huang, Richard M. Pope, The role of Toll-like receptors in rheumatoid arthritis Current Rheumatology Reports. ,vol. 11, pp. 357- 364 ,(2009) , 10.1007/S11926-009-0051-Z
Mitsuhiro Iwahashi, Masahiro Yamamura, Tetsushi Aita, Akira Okamoto, Akiko Ueno, Norio Ogawa, Sachiko Akashi, Kensuke Miyake, Paul J. Godowski, Hirofumi Makino, Expression of toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis Arthritis & Rheumatism. ,vol. 50, pp. 1457- 1467 ,(2004) , 10.1002/ART.20219
Guo-Min Deng, Margareta Verdrengh, Zai-Qing Liu, Andrej Tarkowski, The major role of macrophages and their product tumor necrosis factor α in the induction of arthritis triggered by bacterial DNA containing CpG motifs Arthritis & Rheumatism. ,vol. 43, pp. 2283- 2289 ,(2000) , 10.1002/1529-0131(200010)43:10<2283::AID-ANR16>3.0.CO;2-9
Theodore Pincus, Jane A. Summey, Salvatore A. Soraci, Kenneth A. Wallston, Norman P. Hummon, Assessment of patient satisfaction in activities of daily living using a modified stanford health assessment questionnaire Arthritis & Rheumatism. ,vol. 26, pp. 1346- 1353 ,(1983) , 10.1002/ART.1780261107
Lutz Hamann, Christiane Glaeser, Axel Hamprecht, Michael Gross, Abuzeid Gomma, Ralf R. Schumann, Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis Clinica Chimica Acta. ,vol. 364, pp. 303- 307 ,(2006) , 10.1016/J.CCA.2005.07.017
Kohki Kawane, Mayumi Ohtani, Keiko Miwa, Takuji Kizawa, Yoshiyuki Kanbara, Yoshichika Yoshioka, Hideki Yoshikawa, Shigekazu Nagata, Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages Nature. ,vol. 443, pp. 998- 1002 ,(2006) , 10.1038/NATURE05245
Bali Pulendran, Weiping Cao, 2008: A MyD88 O, DC Immunity. ,vol. 29, pp. 173- 175 ,(2008) , 10.1016/J.IMMUNI.2008.07.006
Agnes Le Bon, David F Tough, Links between innate and adaptive immunity via type I interferon Current Opinion in Immunology. ,vol. 14, pp. 432- 436 ,(2002) , 10.1016/S0952-7915(02)00354-0
Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi, Pathogen Recognition and Innate Immunity Cell. ,vol. 124, pp. 783- 801 ,(2006) , 10.1016/J.CELL.2006.02.015