Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation.

摘要: Summary Very few studies have investigated the effects of exercise on biological parameters involved in vaso-occlusive events sickle cell anaemia (SCA). The aim this study was to test how a mild-moderate endurance modulates oxidative stress, nitric oxide bioavailability and endothelial activation SCA patients healthy individuals. Eleven with 15 subjects completed 20-min duration submaximal cycling at ≈45 Watts. Plasma markers antioxidant activity, were before after exercise. Nitric levels, anti-oxidant capacity, soluble (s)E-selectin sP-selectin did not change response Except for malondialdehyde which increased two groups, other stress remained unchanged both groups Soluble vascular adhesion molecule 1 levels end groups. sL-selectin decreased intercellular only. present data suggest that may undertake physical activities without any acute clinical complications, but care should be taken because significantly some patients.