Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis.

摘要: Cancer cells must adapt their metabolism to meet the energetic and biosynthetic demands that accompany rapid growth of primary tumor colonization distinct metastatic sites. Different stages cascade can also present metabolic challenges disseminating cancer cells. However, little is known regarding how changes in cellular metabolism, both within cell microenvironment, alter ability colonize grow secondary This review examines concept heterogeneity tumor, are metabolically coupled with other comprise stroma. We examine strategies, which engaged by site, change during process. Finally, we discuss adaptations occur as foreign microenvironments influence stromal at sites metastasis. Through a discussion these topics, it clear plasticity programs, allows hostile microenvironments, emerging an important variable may clinical approaches managing disease. Res; 76(18); 5201-8. ©2016 AACR.