Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon
作者： Wentao Chen , Leopold Kong , Stephen Connelly , Julia M. Dendle , Yu Liu
DOI: 10.1021/ACSCHEMBIO.5B01035
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摘要: … G (IgG) is typically the least stable domain in IgG-type … an EAS into the N-glycosylated reverse turn on the C′E … from the serum of a patient with multiple myeloma (Cri, allotype G1m3), (…
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Etsuji Kaneko, Rinpei Niwa, Optimizing Therapeutic Antibody Function BioDrugs. ,vol. 25, pp. 1- 11 ,(2011) , 10.2165/11537830-000000000-00000
Robert L Shields, Angela K Namenuk, Kyu Hong, Y Gloria Meng, Julie Rae, John Briggs, Dong Xie, Jadine Lai, Andrew Stadlen, Betty Li, Judith A Fox, Leonard G Presta, None, High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR Journal of Biological Chemistry. ,vol. 276, pp. 6591- 6604 ,(2001) , 10.1074/JBC.M009483200
Zbyszek Otwinowski, Wladek Minor, Processing of X-ray diffraction data collected in oscillation mode Methods in Enzymology. ,vol. 276, pp. 307- 326 ,(1997) , 10.1016/S0076-6879(97)76066-X
Amber N. Murray, Wentao Chen, Aristotelis Antonopoulos, Sarah R. Hanson, R. Luke Wiseman, Anne Dell, Stuart M. Haslam, David L. Powers, Evan T. Powers, Jeffery W. Kelly, Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity Chemistry & Biology. ,vol. 22, pp. 1052- 1062 ,(2015) , 10.1016/J.CHEMBIOL.2015.06.017
Derry C. Roopenian, Gregory J. Christianson, Thomas J. Sproule, Aaron C. Brown, Shreeram Akilesh, Nadja Jung, Stefka Petkova, Lia Avanessian, Eun Young Choi, Daniel J. Shaffer, Peter A. Eden, Clark L. Anderson, The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs Journal of Immunology. ,vol. 170, pp. 3528- 3533 ,(2003) , 10.4049/JIMMUNOL.170.7.3528
Peter Sondermann, Robert Huber, Vaughan Oosthuizen, Uwe Jacob, The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex. Nature. ,vol. 406, pp. 267- 273 ,(2000) , 10.1038/35018508
Takahiko Ito, Kouhei Tsumoto, Effects of subclass change on the structural stability of chimeric, humanized, and human antibodies under thermal stress Protein Science. ,vol. 22, pp. 1542- 1551 ,(2013) , 10.1002/PRO.2340
Ganesh P. Subedi, Adam W. Barb, The Structural Role of Antibody N-Glycosylation in Receptor Interactions Structure. ,vol. 23, pp. 1573- 1583 ,(2015) , 10.1016/J.STR.2015.06.015
C. Ferrara, S. Grau, C. Jager, P. Sondermann, P. Brunker, I. Waldhauer, M. Hennig, A. Ruf, A. C. Rufer, M. Stihle, P. Umana, J. Benz, Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 12669- 12674 ,(2011) , 10.1073/PNAS.1108455108
Harumi Fukada, Katsutada Takahashi, Julian M. Sturtevant, Differential scanning calorimetric study of the thermal unfolding of Taka-amylase A from Aspergillus oryzae. Biochemistry. ,vol. 26, pp. 4063- 4068 ,(1987) , 10.1021/BI00387A048