GATA6 predicts prognosis and hepatic metastasis of colorectal cancer.
作者： FEI SHEN , JIANGLIN LI , WENSONG CAI , GUANGHUI ZHU , WEILI GU
DOI: 10.3892/OR.2013.2544
关键词:
摘要: Liver metastasis is a major cause of mortality for colorectal cancer (CRC). However, the underlying mechanisms remain largely unknown. GATA binding protein 6 (GATA6), zinc-finger transcription factor, expressed in epithelium. We investigated clinical significance GATA6 and its role invasion CRC. Expression 89 cancerous, 35 adjacent normal 39 liver metastatic samples from CRC patients undergoing surgical resection was detected by immunohistochemical (IHC) methods. The effect on assessed cells shRNA lentivirus or expressed-plasmid transfection. found that expression significantly higher tissues compared with tissues. Aberrant associated metastasis. Kaplan-Meier analysis showed correlated poor overall survival (OS) cell migration established lines were decreased knockdown enhanced overexpression vitro. Thus, aberrant correlates prognosis
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