作者: Sushma Gurumurthy , Ankita Mishra , Joshua Frederick
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摘要: The present disclosure relates to polynucleotides encoding tethered interleukin-12 (IL-12) polypeptides comprising an IL-12 polypeptide and a membrane domain. also vectors the polynucleotides; host cells or vectors, encoded by compositions polynucleotides, cells, delivery agent; uses thereof, including treatment of cancer.