Chemotherapy modulates the biological activity of breast cancer patients plasma: The protective properties of black chokeberry extract
作者： Magdalena Kędzierska , Joanna Malinowska , Bogdan Kontek , Joanna Kołodziejczyk-Czepas , Urszula Czernek
DOI: 10.1016/J.FCT.2012.11.042
关键词:
摘要: In breast cancer patients (before and during anti-cancer therapy) oxidative/nitrative damage to various molecules is observed. Furthermore, treatments may also influence the hemostatic properties of blood platelets plasma. The aim our study was assess effect stress (estimated by measurements levels carbonyl groups 3-nitrotyrosine in proteins--ELISA C-ELISA methods, respectively; lipid peroxidation total antioxidant level--TAS) on selected parameters activity plasma (the process fibrin polymerization lysis) collected from after surgery phases chemotherapy (doxorubicin cyclophosphamide). Subsequently, we evaluated level these presence commercial extract Aronia melanocarpa (Aronox®) vitro. Patients were hospitalized Department Oncological Surgery Chemotherapy Medical University Lodz, Poland. We observed increased biomarkers with or chemotherapy) comparison healthy group. Our further experiments demonstrated investigated differs obtained volunteers. recognize existence a relationship between oxidative (measured groups) changes hemostasis I IV chemotherapy. Moreover, results showed that A. berries significantly reduced, vitro system, patients, different Considering data presented this study, suggest (not only before surgery, but doxorubicin cyclophosphamide induce activity, which contribute thrombosis patients. be regarded as promising new source bioactive natural compounds for
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