Longitudinal Assessment of Genetic and Epigenetic Markers in Oligodendrogliomas

摘要: Purpose: Because little is known about the evolution of genetic and epigenetic changes that occur during tumor progression in oligodendrogliomas, we evaluated these paired early progressive oligodendrogliomas. Experimental Design: 1p36, 19q13, 10q22-26, O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation status were assessed 46 oligodendrogliomas from 23 patients. Results: In tumors, 60.8% low grade compared with only 17% low-grade tumors at recurrence. Of 17 described as pure 76.5% remained this lineage, regardless their grade, whereas others changed to astrocytic tumors. Oligoastrocytic had a significantly higher tendency transform All 1p/19q codeletions phenotypically unchanged, unlike mixed codeletions, which 83% cell lineage. 1p deletion, 80% oligodendroglial progression, 75% an intact phenotype. 10q loss was uncommon both The proportional gain 31% for 1p, 87.5% progression. Conclusions: Pure deletion tend retain phenotype profile no deletions or histology. MGMT more pronounced particularly 1p. These observations suggest late event therefore, chemosensitivity not necessarily related status.