Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomas.

摘要: Abstract Although 1p/19q codeletions define "genetically favorable" oligodendrogliomas, eventual tumor progression and patient death remain constant. Genetic testing is often performed at the time of recurrence, though it unclear whether these or other genetic alterations provide useful prognostic information. We characterized 138 189 (73%) available primary recurrent oligodendroglial neoplasms from 80 patients, utilizing paired FISH probes for 1p32/1q42, 19p13/19q13, CEP7/EGFR, CEP9/p16, PTEN/DMBT1. Patients were followed until (49%), a median follow-up 8.9 years. with codeleted tumors (71%) had an estimated overall survival 14.9 years 3.9 first recurrence. In contrast, those lacking deletions significantly lower survivals 4.7 1.0 year after recurrence (both p < 0.001). This increased in patients remained significant when adjustments made age, grade, type surgical procedure, treatment radiation chemotherapy. Only 1 showed focal EGFR amplification, while 5 developed 10q deletions, mostly high-grade mixed oligoastrocytomas deletions. p16 (9p21) common associated both high grade (p 0.001) = 0.002). Our data suggest that classic oligodendrogliomas: 1) status powerful predictor survival, even recurrence; 2) are progression-associated alterations; 3) amplifications sufficiently rare to possibility alternate diagnoses.