Cytogenetics of Melanocytic Tumors
作者： Annette H. Parmiter , Peter C. Nowell
DOI: 10.1038/JID.1993.46
关键词:
摘要: Chromosome studies of human melanocytic tumors have demonstrated non-random karyotypic abnormalities chromosomes 1, 6, 7, 9, and 10. These visible genetic alterations may provide clues to the location oncogenes suppressor genes involved in development lesions from benign nevus metastatic melanoma, mechanisms by which function these is altered. To date, however, none specific growth regulatory important this neoplastic progression has been identified, with possible exception erbB oncogene later stages. Recent results other do suggest, that combined cytogenetic molecular approach will soon lead recognition a number genes, both inherited somatically altered, significant clinical applications follow.
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jidonline.org参考文章(51)
Anthony P. Albino, The Role of Oncogenes in the Pathogenesis of Malignant Melanoma Springer, Boston, MA. pp. 3- 39 ,(1987) , 10.1007/978-1-4613-2043-2_1
R.F. Kefford, J. Salmon, H.M. Shaw, J.A. Donald, W.H. McCarthy, Hereditary melanoma in Australia. Variable association with dysplastic nevi and absence of genetic linkage to chromosome 1p. Cancer Genetics and Cytogenetics. ,vol. 51, pp. 45- 55 ,(1991) , 10.1016/0165-4608(91)90007-H
C. Witkowski, E. Meese, J. Trent, D. Millikin, B. Vogelstein, Loss of Heterozygosity for Loci on the Long Arm of Chromosome 6 in Human Malignant Melanoma Cancer Research. ,vol. 51, pp. 5449- 5453 ,(1991)
Elisabeth Ralfkiaer, Jonathan R. Stretch, David P. Lane, Kevin C. Gatter, Adrian L. Harris, Expression of mutant p53 in melanoma. Cancer Research. ,vol. 51, pp. 5976- 5979 ,(1991)
Mary E. Harper, Genoveffa Franchini, Jamie Love, Melvin I. Simon, Robert C. Gallo, Flossie Wong-Staal, Chromosomal sublocalization of human c-myb and c-fes cellular onc genes Nature. ,vol. 304, pp. 169- 171 ,(1983) , 10.1038/304169A0
J. Trent, E. Stanbridge, H. McBride, E. Meese, G Casey, D. Araujo, C. Witkowski, R. Nagle, Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6. Science. ,vol. 247, pp. 568- 571 ,(1990) , 10.1126/SCIENCE.2300817
Sverre Heim, Nils Mandahl, Kristina Arheden, Beppino C. Giovanella, Sun Ock Yim, John S. Stehlin, Felix Mitelman, Multiple karyotypic abnormalities, including structural rearrangements of 11p, in cell lines from malignant melanomas Cancer Genetics and Cytogenetics. ,vol. 35, pp. 5- 20 ,(1988) , 10.1016/0165-4608(88)90115-X
Arie van Haeringen, Wilma Bergman, Marcel R. Nelen, Ellien van der Kooij-Meijs, Iems Hendrikse, Juul Th. Wijnen, Paul Meera Khan, Eduard C. Klasen, Rune R. Frants, Exclusion of the dysplastic nevus syndrome (DNS) locus from the short arm of chromosome 1 by linkage studies in dutch families Genomics. ,vol. 5, pp. 61- 64 ,(1989) , 10.1016/0888-7543(89)90086-4
Marianne Roser, Anette Böhm, Maike Oldigs, Michael Weichenthal, Uta Reimers, Ute Schmidt-Preuss, Eckhard W. Breitbart, Hugo W. Rüdiger, Ultraviolet-induced formation of micronuclei and sister chromatid exchange in cultured fibroblasts of patients with cutaneous malignant melanoma. Cancer Genetics and Cytogenetics. ,vol. 41, pp. 129- 137 ,(1989) , 10.1016/0165-4608(89)90117-9
N.G.J. Jaspers, E.J.M. Roza-de Jongh, I.G. Donselaar, J.T.M. Van Velzen-Tillemans, J.O. van Hemel, Ph. Rümke, A.W.M. van der Kamp, Sister chromatid exchanges, hyperdiploidy and chromosomal rearrangements studied in cells from melanoma-prone individuals belonging to families with the dysplastic nevus syndrome. Cancer Genetics and Cytogenetics. ,vol. 24, pp. 33- 43 ,(1987) , 10.1016/0165-4608(87)90081-1