Limitations of animal models of Parkinson's disease.

摘要: Most cases of Parkinson's disease (PD) are sporadic. When choosing an animal model for idiopathic PD, one must consider the extent similarity or divergence between physiology, anatomy, behavior, and regulation gene expression humans animal. Rodents nonhuman primates used most frequently in PD research because when a Parkinsonian state is induced, they mimic many aspects PD. These models have been useful our understanding etiology provide means testing new treatments. However, current often fall short replicating true pathophysiology occurring thus results from do not translate to clinic. In this paper we will explain limitations why their use inappropriate study some