Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH.

摘要: Summary Objective  Ghrelin is a novel gastric peptide known to stimulate GH secretion, but the relationship between ghrelin and GH-insulin-like growth factor (IGF)-1 axis in excess or deficiency poorly understood. This study investigated dysregulation of secretion acromegaly its short-term postoperative recovery. Methods  A prospective was conducted on eight patients who underwent complete transsphenoidal resection GH-producing pituitary adenomas (acromegaly group) 22 for endocrinologically nonfunctioning tumours (control group). Active total plasma levels were measured serially before after surgery. Results  Preoperative active concentrations (mean ± SD; fmol/ml) significantly reduced acromegalic when compared with those controls (9·6 ± 4·3 157·4 ± 65·6 vs. 21·8 ± 13·0 267·1 ± 111·4; P = 0·023 P = 0·021, respectively). Both still suppressed Day 7 group control (11·7 ± 4·3 197·8 ± 68·9 22·5 ± 12·6 302·7 ± 100·0; P = 0·038 P = 0·018, The ratios not different two groups operation. In patients, remained even normalization serum levels. Conclusions  putative negative feedback mechanism may part account low observed persist GH.