Lesion of serotonergic neurons antagonizes clonidine-induced suppression of avoidance behavior and locomotor activity in rats
作者： Wojciech Kostowski , Adam Plaznik , Olgierd Pucilowski , Andrzej Bidzinski , Miros?awa Hauptmann
DOI: 10.1007/BF00422414
关键词:
摘要: The effects of clonidine on avoidance acquisition and locomotor activity were studied in male Wistar rats with 5,6-dihydroxytryptamine (5,6-DHT) lesions the median raphe nucleus. Lesioned animals showed marked depletion forebrain serotonin 5-hydroxyindole acetic acid concentrations. Clonidine (0.2 mg/kg IP a single daily dose for 6 consecutive days) inhibited reduced unlesioned rats. In 5,6-DHT failed to produce depressive effects. resistance raphe-lesioned is discussed basis possible interaction between noradrenergic serotonergic brain systems.
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