Very early changes in circulating T3 and rT3 during development of metabolic derangement in diabetic patients.

作者: Sten Madsbad , Peter Laurberg , Jørgen Weeke , Hans Ørskov , Ole K. Faber

DOI: 10.1111/J.0954-6820.1981.TB11612.X

关键词:

摘要: Alterations in circulating iodothyronines were studied 15 juvenile type diabetic patients during the development of metabolic derangement after withdrawal insulin. By means measurements C peptide, one group with and without residual beta-cell function had been selected. In both groups there was a gradual decrease serum T3 12-hour period insulin, while an increase rT3 observed 4-6 hours. The alterations significantly more pronounced than function.

参考文章(13)
HAROLD E. CARLSON, ERNST J. DRENICK, INDER J. CHOPRA, JEROME M. HERSHMAN, Alterations in basal and TRH-stimulated serum levels of thyrotropin, prolactin, and thyroid hormones in starved obese men. The Journal of Clinical Endocrinology and Metabolism. ,vol. 45, pp. 707- 713 ,(1977) , 10.1210/JCEM-45-4-707
J. Weeke, H. Orskov, Ultrasensitive radioimmunoassay for direct determination of free triiodothyronine concentration in serum Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 35, pp. 237- 244 ,(1975) , 10.1080/00365517509095735
Kenneth D. Burman, Richard C. Dimond, Grace S. Harvey, John T. O'Brian, Leon P. Georges, Joseph Bruton, Frances D. Wright, Leonard Wartofsky, Glucose modulation of alterations in serum iodothyronine concentrations induced by fasting. Metabolism-clinical and Experimental. ,vol. 28, pp. 291- 299 ,(1979) , 10.1016/0026-0495(79)90098-2
C. S. PITTMAN, A. K. SUDA, J. B. CHAMBERS, H. G. MCDANIEL, G. Y. RAY, B. K. PRESTON, Abnormalities of thyroid hormone turnover in patients with diabetes mellitus before and after insulin therapy. The Journal of Clinical Endocrinology and Metabolism. ,vol. 48, pp. 854- 860 ,(1979) , 10.1210/JCEM-48-5-854
Peter Laurberg, Jørgen Weeke, Radioimmunological determination of reverse triiodothyronine in unextracted serum and serum dialysates Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 37, pp. 735- 739 ,(1977) , 10.3109/00365517709101858
Fereidoun Azizi, Effect of dietary composition on fasting-induced changes in serum thyroid hormones and thyrotropin Metabolism-clinical and Experimental. ,vol. 27, pp. 935- 942 ,(1978) , 10.1016/0026-0495(78)90137-3
C.S. Pittman, A.K. Suda, J.B. Chambers, G.Y. Ray, Impaired 3,5,3′-triiodothyronine (T3) production in diabetic patients Metabolism-clinical and Experimental. ,vol. 28, pp. 333- 338 ,(1979) , 10.1016/0026-0495(79)90103-3
J. Saunders, S. E. H. Hall, P. H. S�nksen, Thyroid hormones in insulin requiring diabetes before and after treatment. Diabetologia. ,vol. 15, pp. 29- 32 ,(1978) , 10.1007/BF01219324
R. NAEIJE, J. GOLSTEIN, N. CLUMECK, H. MEINHOLD, K. W. WENZEL, L. VANHAELST, A LOW T3 SYNDROME IN DIABETIC KETOACIDOSIS Clinical Endocrinology. ,vol. 8, pp. 467- 472 ,(1978) , 10.1111/J.1365-2265.1978.TB02183.X
ABHAY K. SUDA, CONSTANCE S. PITTMAN, TAEKO SHIMIZU, JOSEPH B. CHAMBERS, The production and metabolism of 3,5,3'-triiodothyronine and 3,3',5-triiodothyronine in normal and fasting subjects. The Journal of Clinical Endocrinology and Metabolism. ,vol. 47, pp. 1311- 1319 ,(1978) , 10.1210/JCEM-47-6-1311