Recent progress in studies of factors that elicit pancreatic β-cell expansion

摘要: The loss of or decreased functional pancreatic β-cell is a major cause type 1 and 2 diabetes. Previous studies have shown that adult β-cells can maintain their ability for low level turnover through replication neogenesis. Thus, strategy to prevent treat diabetes would be enhance the increase mass β-cells. Consequently, much effort has been devoted identify factors effectively induce expansion. This review focuses on recent reports small molecules protein promote