Hepatitis C and hepatitis B in the etiology of hepatocellular carcinoma in the Japanese population.

摘要: Abstract We conducted case-control studies of hepatocellular carcinoma (HCC) and liver cirrhosis (LC) in relation to hepatitis C virus (HCV) B infection, involving 91 patients with HCC, 75 LC who had no evidence 410 control subjects from the Japanese population. Serum antibody HCV (anti-HCV) was detected by both enzyme-linked immunosorbent assay recombinant immunoblot 51, 3% LC, controls, respectively, whereas corresponding prevalence serum surface antigen (HBsAg) 21, 11, 2%, respectively. The relative risks (and 95% confidence intervals) for presence anti-HCV were estimated as 52.3 (23.9–114.3) HCC 64.4 (27.4–151.4) LC. These values exceeded risk (15.3) that (6.1) positive HBsAg. Among male or rates very high blood recipients (about 70%), heavy drinkers (46–62%), those identifiable factors (65–75%), indicating possible transmission via routes other than transfusion. No significant difference status observed between groups. It notable much less prevalent among HBsAg-positive HBsAg-negative ones. There a slight moderate increase after adjustment status. results indicate that, Japan, role infection etiology is extremely large seems be more important chronic infection.